The immune and metabolic changes with age in giant panda blood by combined transcriptome and DNA methylation analysis

The immune and metabolic changes with age in giant panda blood by combined transcriptome and DNA methylation analysis

Giant panda (Ailuropoda melanoleuca) is an endangered mammalian species. Exploring immune and metabolic changes that happen in giant pandas with age is vital for his or her safety. In this examine, we systematically investigated the physiological and biochemical indicators in blood, in addition to the transcriptome, and methylation profiles of younger, grownup, and outdated giant pandas. The white blood cell (WBC), neutrophil (NEU) counts and hemoglobin (HGB) concentrations elevated considerably with age (younger to grownup), and some indicators associated to blood glucose and lipids additionally modified considerably with age. In the transcriptome analysis, differentially expressed genes (DEGs) had been discovered in comparisons of the younger and grownup (257), grownup and outdated (20), younger and outdated (744) teams.

Separation of the DEGs into eight profiles in keeping with the expression pattern utilizing quick time-series expression miner (STEM) software program revealed that the majority DEGs had been downregulated with age. Functional analysis confirmed that the majority DEGs had been related with illness and that these DEGs had been additionally related with the immune system and metabolism. Furthermore, gene methylation in giant pandas decreased globally with age, and the expression of CCNE1CD79AIL1R1, and TCF7 confirmed a extremely destructive correlation with their diploma of methylation. These outcomes point out that the giant panda’s immune operate improves steadily with age (younger to grownup), and that changes in the methylation profile are concerned in the consequences of age on immune and metabolic features. These outcomes have vital implications for the understanding and conservation of giant pandas.

 

CRISPR-mediated modification of DNA methylation sample in the brand new period of most cancers remedy

 

In the final 2 a long time, all kinds of research have been carried out on epigenetics and its position in numerous cancers. A serious mechanism of epigenetic regulation is DNA methylation, together with aberrant DNA methylation variations similar to hypermethylation and hypomethylation in the promoters of essential genes, that are generally detected in tumors and mark the early phases of most cancers growth. Therefore, epigenetic remedy has been of particular significance in the final decade for most cancers remedy. In epigenetic remedy, all efforts are made to modulate gene expression to the traditional standing.

Importantly, current research have proven that epigenetic remedy is specializing in the brand new gene enhancing know-how, CRISPR-Cas9. This software was discovered to have the ability to successfully modulate gene expression and alter virtually any sequence in the genome of cells, ensuing in occasions similar to a change in acetylation, methylation, or histone modifications. Of notice, the CRISPR-Cas9 system can be utilized for the remedy of cancers brought about by epigenetic alterations. The CRISPR-Cas9 system has larger benefits than different accessible strategies, together with potent exercise, simple design and excessive velocity in addition to the power to focus on any DNA or RNA website. In this evaluate, we described epigenetic modulators, which can be utilized in the CRISPR-Cas9 system, in addition to their features in gene expression alterations that result in most cancers initiation and development.

In addition, we surveyed numerous species of CRISPR-dead Cas9 (dCas9) techniques, a mutant model of Cas9 with no endonuclease exercise. Such techniques are relevant in epigenetic remedy for gene expression modulation via chemical group enhancing on nucleosomes and chromatin transforming, which lastly return the cell to the traditional standing and stop most cancers development.

 The immune and metabolic changes with age in giant panda blood by combined transcriptome and DNA methylation analysis
The immune and metabolic changes with age in giant panda blood by combined transcriptome and DNA methylation analysis

 

DNA Methylation-Based Panel Predicts Survival of Patients With Clear Cell Renal Cell Carcinoma and Its Correlations With Genomic Metrics and Tumor Immune Cell Infiltration

 

DNA methylation based mostly prognostic issue for sufferers with clear cell renal cell carcinoma (ccRCC) stays unclear. In the current examine, we recognized survival-related DNA methylation websites based mostly on the differentially methylated DNA CpG websites between regular renal tissue and ccRCC. Then, these survival-related DNA methylation websites had been included into an elastic internet regularized Cox proportional hazards regression (CoxPH) mannequin to construct a DNA methylation-based panel, which might stratify sufferers into totally different survival teams with glorious accuracies in the coaching set and check set.

Zebularine (DNA methylation inhibitor)

SIH-560-25MG 25 mg
EUR 311
Description: The substance Zebularine is a dna methylation inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml).

Zebularine (DNA methylation inhibitor)

SIH-560-5MG 5 mg
EUR 126
Description: The substance Zebularine is a dna methylation inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml).

DNA Methylation Detection Kit

K5082100 1 kit
EUR 344

Epizen DNA Methylation Kit

Z4201-050 50 Rxns
EUR 327

Epizen DNA Methylation Kit

Z4201-200 4x50 rxns
EUR 968

EpiArt DNA Methylation Bisulfite Kit

EM101-01 50 rxn
EUR 241

EpiArt DNA Methylation Bisulfite Kit

EM101-02 200 rxn
EUR 609

EpiArt DNA Methylation Library Kit

NE101-01 24 rxn
EUR 889

EpiArt DNA Methylation Library Kit

NE101-02 96 rxn
EUR 2928

DNA Methylation/Hydroxymethylation Standard Set

P-1025 2 µg/standard x 3
EUR 570.55
Description: reagents widely cited

Epizen DNA Methylation-Direct Kit

Z4001-050 50 Rxns
EUR 428

Epizen DNA Methylation-Direct Kit

Z4001-200 4x50 rxns
EUR 1036

Epizen DNA Methylation-Gold Kit

Z4101-050 50 Rxns
EUR 361

Epizen DNA Methylation-Gold Kit

Z4101-200 4x50 rxns
EUR 901

DNA Methylation Antibody Panel Pack I

C20000
EUR 382.05
Description: Ask the seller for details

Methylamp Global DNA Methylation Quantification Ultra Kit

P-1014B 96 Assays
EUR 947.55
Description: reagents widely cited

Methyflash m6A DNA Methylation ELISA Kit (Colorimetric)

P-9010 96 Assays
EUR 788.05
Description: The best epigenetics products

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 70
Description: Bioscience Mol Bio; DNA Ladder

MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)

P-1030 96 reactions
EUR 860.55
Description: Ask the seller for details

Global DNA Methylation ELISA Kit (5?-methyl-2?-deoxycytidine Quantitation)

STA-380 96 assays
EUR 624
Description: The Global DNA Methylation ELISA Kit is a competitive ELISA for the quantitative measurement of 5-methylcytosine (5MedCyd). The unknown 5MedCyd samples or 5MedCyd standards are first added to a 5MedCyd DNA conjugate coated EIA plate. After a brief incubation, an anti-5MedCyd monoclonal antibody is added, followed by an HRP conjugated secondary antibody. The 5MedCyd content in unknown samples is determined by comparison with a predetermined 5MedCyd standard curve.

Global DNA Methylation ELISA Kit (5?-methyl-2?-deoxycytidine Quantitation)

STA-380-5 5 x 96 assays
EUR 2503
Description: The Global DNA Methylation ELISA Kit is a competitive ELISA for the quantitative measurement of 5-methylcytosine (5MedCyd). The unknown 5MedCyd samples or 5MedCyd standards are first added to a 5MedCyd DNA conjugate coated EIA plate. After a brief incubation, an anti-5MedCyd monoclonal antibody is added, followed by an HRP conjugated secondary antibody. The 5MedCyd content in unknown samples is determined by comparison with a predetermined 5MedCyd standard curve.

Mitomycin C (DNA synthesis inhibitor)

SIH-246-10MG 10 mg
EUR 149
  • The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specif
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Description: The substance Mitomycin C is a dna synthesis inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is dark purple crystalline solid which is May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm).

Mitomycin C (DNA synthesis inhibitor)

SIH-246-50MG 50 mg
EUR 373
  • The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specif
  • Show more
Description: The substance Mitomycin C is a dna synthesis inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is dark purple crystalline solid which is May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm).

Inhibitor of DNA Binding 2 Protein

20-abx261029
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Inhibitor of DNA Binding 1 Protein

20-abx262603
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Histone H3K4 Methylation Antibody Panel Pack

C10005 3 x 25 µg
EUR 628.55
Description: Ask the seller for details

Histone H3K9 Methylation Antibody Panel Pack

C10006 3 x 25 µg
EUR 628.55
Description: fast delivery possible

Histone H3K27 Methylation Antibody Panel Pack

C10007 3 x 25 µg
EUR 628.55
Description: The best epigenetics products

Histone H3K36 Methylation Antibody Panel Pack

C10008 3 x 25 µg
EUR 628.55
Description: reagents widely cited

Histone H3K79 Methylation Antibody Panel Pack

C10009 3 x 25 µg
EUR 628.55
Description: kits suitable for this type of research

Histone H4K20 Methylation Antibody Panel Pack

C10012 3 x 25 µg
EUR 628.55
Description: The best epigenetics products

Histone H3R2 Methylation Antibody Panel Pack

C10015 3 x 25 µg
EUR 628.55
Description: Ask the seller for details

Histone H3R8 Methylation Antibody Panel Pack

C10016 3 x 25 µg
EUR 628.55
Description: fast delivery possible

Histone H3R17 Methylation Antibody Panel Pack

C10017 3 x 25 µg
EUR 628.55
Description: The best epigenetics products

Histone H3R26 Methylation Antibody Panel Pack

C10018 3 x 25 µg
EUR 628.55
Description: reagents widely cited

Histone H4R3 Methylation Antibody Panel Pack

C10019 3 x 25 µg
EUR 628.55
Description: kits suitable for this type of research

metallo-b-lactamase inhibitor, DNA aptamer, unlabeled

AD-129-U Custom Ask for price

metallo-b-lactamase inhibitor, DNA aptamer, Biotinylated

AD-159-B Custom Ask for price

Metallo-b-lactamase inhibitor, DNA aptamer, unlabeled

AD-159-U Custom Ask for price

DNA-binding protein inhibitor ID-2 Antibody

20-abx109731
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 2 (ID2) Antibody

20-abx213770
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 2 (ID2) Antibody

20-abx213866
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 2 (ID2) Antibody

abx332197-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 2 (ID2) Antibody

20-abx241545
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 2 (ID2) Antibody

20-abx241669
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

EpiQuik Global Histone H3K4 Methylation Assay Kit

P-3017 96 Assays
EUR 889.55
Description: reagents widely cited

EpiQuik Global Histone H3K9 Methylation Assay Kit

P-3018 96 Assays
EUR 889.55
Description: Ask the seller for details

EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

P-9005 96 Reactions
EUR 788.05
Description: The best epigenetics products

EpiQuik m6A RNA Methylation Quantification Kit (Fluorometric)

P-9008 96 Assays
EUR 788.05
Description: reagents widely cited

metallo-b-lactamase inhibitor, DNA aptamer, FITC labelled

AD-159-F Custom Ask for price

DNA-Binding Protein Inhibitor ID-2 (ID2) Antibody

20-abx125980
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-2 (ID2) Antibody

abx117021-100ug 100 ug
EUR 467
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

20-abx113131
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-binding protein inhibitor ID-2 Antibody (HRP)

20-abx108187
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-2 (ID2) Antibody

20-abx000949
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

abx149875-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

20-abx133636
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

abx034601-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

abx034601-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

DNA-binding protein inhibitor ID-2 Antibody (Biotin)

20-abx105349
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-binding protein inhibitor ID-2 Antibody (FITC)

20-abx106768
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

20-abx009130
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

20-abx013499
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

20-abx005928
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

20-abx004116
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

abx030201-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

abx030201-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

abx026408-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

abx026408-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-2 (ID2) Antibody

20-abx015888
  • EUR 411.00
  • EUR 119.00
  • 100 ul
  • 10 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-2 (ID2) Antibody

abx015889-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (Id1) Antibody

20-abx216130
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

20-abx333779
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

20-abx241670
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-1 (ID1) Antibody

abx234114-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody

abx234115-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody

20-abx301095
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Human DNA-binding protein inhibitor ID-1 (ID1)

1-CSB-EP010966HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 32.1 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human DNA-binding protein inhibitor ID-1(ID1) expressed in E.coli

Human DNA-binding protein inhibitor ID-2 (ID2)

1-CSB-EP010967HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 30.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human DNA-binding protein inhibitor ID-2(ID2) expressed in E.coli

Recombinant human DNA-binding protein inhibitor ID-1

P1872 100ug Ask for price
  • Uniprot ID: P41134
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human DNA-binding protein inhibitor ID-1

Target of Methylation-Induced Silencing 1 (TMS1) Antibody

abx411999-01mg 0.1 mg
EUR 509
  • Shipped within 1 week.

Target of Methylation-Induced Silencing 1 (TMS1) Antibody

abx430019-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Target of Methylation-Induced Silencing 1 (TMS1) Antibody

abx430020-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Target of Methylation-Induced Silencing 1 (TMS1) Antibody

abx238809-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

EpiQuik In Situ Histone H3K4 Methylation Assay Kit

P-3015 2x96 assays
EUR 1063.55
Description: kits suitable for this type of research

EpiQuik In Situ Histone H3K9 Methylation Assay Kit

P-3016 2x96 assays
EUR 1063.55
Description: fast delivery possible

EpiQuik Global Histone H3K27 Tri-Methylation Assay Kit

P-3020 96 Assays
EUR 889.55
Description: fast delivery possible

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

20-abx328696
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody (HRP)

20-abx335424
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody (FITC)

20-abx335425
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-3 (ID3) Antibody (Biotin)

20-abx335426
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

abx332646-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody (HRP)

20-abx316953
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody (FITC)

20-abx316954
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA-Binding Protein Inhibitor ID-4 (ID4) Antibody (Biotin)

20-abx316955
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

20-abx212077
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

20-abx212156
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

20-abx212157
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Inhibitor Of DNA Binding 4, HLH Protein (ID4) Antibody

20-abx212993
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

ID1 Inhibitor of DNA Binding 1 Human Recombinant Protein

PROTP41134 Regular: 10ug
EUR 317
Description: ID1 Human Recombinant produced in E. coli is a single polypeptide chain containing 178 amino acids (1-155) and having a molecular mass of 18.5kDa. ID1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ID2 Inhibitor of DNA Binding 2 Human Recombinant Protein

PROTQ02363 Regular: 20ug
EUR 317
Description: ID2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids (1-134 a.a.) and having a molecular mass of 17kDa. ID2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Histone H3 Methylation Antibody Panel Pack I ? Active Genes

C10000 4 x 25 µg
EUR 773.55
Description: Ask the seller for details

Histone H3 Methylation Antibody Panel Pack I ? Repression Genes

C10001 4 x 25 µg
EUR 773.55
Description: fast delivery possible

Histone H3 Methylation Antibody Panel Pack II ? Active Genes

C10002 3 x 25 µg
EUR 628.55
Description: The best epigenetics products

Histone H3 Methylation Antibody Panel Pack II ? Repression Genes

C10003 4 x 25 µg
EUR 773.55
Description: reagents widely cited

Histone H3 Methylation Antibody Panel Pack III ? Active Genes

C10004 4 x 25 µg
EUR 773.55
Description: kits suitable for this type of research

EpiQuik In Situ Histone H3K27 Tri-Methylation Assay Kit

P-3014T 2x96 assays
EUR 1063.55
Description: The best epigenetics products

MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric)

P-9009 48 reactions
EUR 496.6
Description: kits suitable for this type of research

Goat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E06D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E06D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E06D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E06D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E06D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E06D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 2(ID2) ELISA kit

E01D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 2(ID2) ELISA kit

E01D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 2(ID2) ELISA kit

E01D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 4(ID4) ELISA kit

E01D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 4(ID4) ELISA kit

E01D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human DNA binding protein inhibitor ID 4(ID4) ELISA kit

E01D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E02D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E02D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 2(ID2) ELISA kit

E02D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E02D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E02D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA binding protein inhibitor ID 4(ID4) ELISA kit

E02D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 2(ID2) ELISA kit

E03D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 2(ID2) ELISA kit

E03D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 2(ID2) ELISA kit

E03D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 4(ID4) ELISA kit

E03D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 4(ID4) ELISA kit

E03D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse DNA binding protein inhibitor ID 4(ID4) ELISA kit

E03D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 2(ID2) ELISA kit

E04D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 2(ID2) ELISA kit

E04D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 2(ID2) ELISA kit

E04D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 4(ID4) ELISA kit

E04D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 4(ID4) ELISA kit

E04D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit DNA binding protein inhibitor ID 4(ID4) ELISA kit

E04D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 2(ID2) ELISA kit

E08D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 2(ID2) ELISA kit

E08D0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 2(ID2) ELISA kit

E08D0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 4(ID4) ELISA kit

E08D0301-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 4(ID4) ELISA kit

E08D0301-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog DNA binding protein inhibitor ID 4(ID4) ELISA kit

E08D0301-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine DNA binding protein inhibitor ID 4(ID4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey DNA binding protein inhibitor ID 2(ID2) ELISA kit

E09D0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey DNA binding protein inhibitor ID 2(ID2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

External validation urged that the DNA methylation-based panel might successfully distinguish regular controls from tumor samples and classify sufferers into metastasis group and non-metastasis group. The nomogram containing DNA methylation-based panel was dependable in scientific settings. Higher complete mutation quantity, SCNA stage, and MATH rating had been related with increased methylation threat. The innate immune, ratio between CD8+T cell versus Treg cell in addition to Th17 cell versus Th2 cell had been considerably decreased in excessive methylation threat group. In inclusion, we developed a DNA methylation-based panel which may be unbiased prognostic issue in ccRCC. Patients with increased methylation threat had been related genomic alteration and poor immune microenvironment.

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Although DNA methylation is one of the best characterised epigenetic mark, the mechanism by which it’s focused to particular areas within the genome stays unclear. Recent research have revealed that local DNA methylation profiles may be dictated by cis-regulatory DNA sequences that primarily function by way of DNA-binding components. Consistent with this discovering, we now have lately proven that disruption of CTCF-binding sites by uncommon single nucleotide variants (SNVs) can underlie cis-linked DNA methylation modifications in sufferers with congenital anomalies. These knowledge increase the speculation that uncommon genetic variation at transcription factor binding sites (TFBSs) may contribute to local DNA methylation patterning.

In this work, by combining blood genome-wide DNA methylation profiles, entire genome sequencing-derived SNVs from 247 unrelated people together with 133 predicted TFBS motifs derived from ENCODE ChIP-Seq knowledge, we noticed an affiliation between the disruption of binding sites for a number of TFs by uncommon SNVs and excessive DNA methylation values at each local and, to a lesser extent, distant CpGs. While nearly all of these modifications affected solely single CpGs, 24% had been related to a number of outlier CpGs inside ±1kb of the disrupted TFBS. Interestingly, disruption of functionally constrained sites inside TF motifs result in bigger DNA methylation modifications at close by CpG sites. Altogether, these findings recommend that uncommon SNVs at TFBS negatively affect TF-DNA binding, which might result in an altered local DNA methylation profile.

Furthermore, subsequent integration of DNA methylation and RNA-Seq profiles from cardiac tissues enabled us to watch an affiliation between uncommon SNV-directed DNA methylation and outlier expression of close by genes. In conclusion, our findings not solely present insights into the impact of uncommon genetic variation at TFBS on shaping local DNA methylation and its penalties on genome regulation, but additionally present a rationale to include DNA methylation knowledge to interpret the purposeful function of uncommon variants.

 

Inhibition of DNA Methylation in Picochlorum soloecismus Alters Algae Productivity

 

Eukaryotic organisms regulate the group, construction, and accessibility of their genomes by way of chromatin reworking that may be inherited as epigenetic modifications. These DNA and histone protein modifications are in the end liable for an organism’s molecular adaptation to the surroundings, leading to distinctive phenotypes. Epigenetic manipulation of algae holds but untapped potential for the optimization of biofuel manufacturing and bioproduct formation; nonetheless, epigenetic equipment and modes-of-action haven’t been nicely characterised in algae.

We sought to find out the extent to which the biofuel platform species Picochlorum soloecismus makes use of DNA methylation to manage its genome. We discovered candidate genes with domains for DNA methylation within the P. soloecismus genome. Whole-genome bisulfite sequencing revealed DNA methylation in all three cytosine contexts (CpG, CHH, and CHG). While world DNA methylation is low general (∼1.15%), it happens in considerable portions (12.1%) in CpG dinucleotides in a bimodal distribution in all genomic contexts, although terminators include the best variety of CpG sites per kilobase. The P. soloecismus genome turns into hypomethylated throughout the progress cycle in response to nitrogen hunger.

 

Algae cultures had been handled each day throughout the expansion cycle with 20 μM 5-aza-2′-deoxycytidine (5AZA) to inhibit propagation of DNA methylation in daughter cells. 5AZA remedy considerably elevated optical density and ahead and aspect scatter of cells throughout the expansion cycle (16 days). This enhance in cell measurement and complexity correlated with a big enhance (∼66%) in lipid accumulation. Site particular CpG DNA methylation was considerably altered with 5AZA remedy over the time course, although nitrogen hunger itself induced vital hypomethylation in CpG contexts. Genes concerned in a number of organic processes, together with fatty acid synthesis, had altered methylation ratios in response to 5AZA; we hypothesize that these modifications are doubtlessly liable for the phenotype of early induction of carbon storage as lipids. This is the primary report back to make the most of epigenetic manipulation methods to change algal physiology and phenotype. Collectively, these knowledge recommend these methods could be utilized to fine-tune metabolic responses, alter progress, and improve environmental adaption of microalgae for desired outcomes.

 Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles
Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

 

DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters

Background: Injuries from publicity to explosions rose dramatically throughout the Iraq and Afghanistan wars, which motivated investigation of blast-related neurotrauma. We have undertaken human research involving navy “breachers” -exposed to managed, low-level blast throughout a 3-days explosive breaching course.
Methods: We screened epigenetic profiles in peripheral blood samples from 59 topics (in two separate U.S. Military coaching classes) utilizing Infinium MethylationEPIC BeadChips. Participants had various numbers of exposures to blast over their navy careers. Daily self-reported physiological signs had been recorded. Tinnitus, reminiscence issues, complications, and sleep disturbances are most ceaselessly reported.
Results: We recognized 14 considerably differentially methylated areas (DMRs) inside genes related to cumulative blast publicity in contributors with excessive relative to low cumulative blast publicity. Notably, NTSR1 and SPON1 had been considerably differentially methylated in excessive relative to low blast uncovered teams, suggesting that sleep dysregulation could also be altered in response to power cumulative blast publicity.
5-Azacytidine (DNA hypomethylation agent)
SIH-345-250MG 250 mg
EUR 174
  • DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells
  • induces
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Description: The substance 5-Azacytidine is a dna hypomethylation agent. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 25 mg/ml DMSO or 12 mg/ml Water.
5-Azacytidine (DNA hypomethylation agent)
SIH-345-50MG 50 mg
EUR 105
  • DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells
  • induces
  • Show more
Description: The substance 5-Azacytidine is a dna hypomethylation agent. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 25 mg/ml DMSO or 12 mg/ml Water.
100 BP DNA LADDER, 500UL PER KIT
M-DNA-100BP 1/pk
EUR 73
Description: Bioscience Mol Bio; DNA Ladder
1 KB DNA LADDER, 500UL PER KIT
M-DNA-1KB 1/pk
EUR 70
Description: Bioscience Mol Bio; DNA Ladder
Antifungal agent 1
HY-102025 50mg
EUR 2220
Antitumor agent-3
HY-15961 5mg
EUR 533
Bifunctional Antiplatelet Agent
H-1662.0001 1.0mg
EUR 297
Description: Sum Formula: C53H103N25O13; CAS# [148796-92-3]
Bifunctional Antiplatelet Agent
H-1662.0005 5.0mg
EUR 1093
Description: Sum Formula: C53H103N25O13; CAS# [148796-92-3]
Antiulcer Agent 1
HY-U00122 1mg
EUR 326
Anticonvulsant agent 1
HY-U00348 5mg
EUR 2846
Bronchospasmolytic agent 1
HY-U00405 1mg
EUR 463
Antitumor agent-4
HY-U00414 20mg
EUR 13439
Sufa synergist agent(SSA)
AG243 1 mg
EUR 523
Sufa synergist agent(SSA)
AT243 1mg
EUR 1368
Anti-inflammatory agent 1
HY-U00273 10mg
EUR 1455
Anti-inflammatory agent 2
HY-U00299 20mg
EUR 4803
Anti-neurodegeneration agent 1
HY-U00314 20mg
EUR 4803
Vildagliptin (Anti-diabetic agent)
SIH-567-100MG 100 mg
EUR 231
  • Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results i
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Description: The substance Vildagliptin is a anti-diabetic agent. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml).
Vildagliptin (Anti-diabetic agent)
SIH-567-20MG 20 mg
EUR 115
  • Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results i
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Description: The substance Vildagliptin is a anti-diabetic agent. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml).
Anti-Heart Failure Agent 1
HY-101729 20mg
EUR 10629
10X Fish Gelatin Blocking Agent
22010 100ML
EUR 112
Description: Minimum order quantity: 1 unit of 100ML
Bialaphos sodium - bar gene selective agent
B013-100MG 100 mg
EUR 155
Bialaphos sodium - bar gene selective agent
B013-500MG 500 mg
EUR 574
Attoglow Western Blot Analysis Kit:Blocking Agent
K3171250-3 40 g
EUR 109
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
BCA Protein Assay Kit - Reducing Agent Compatible
K818-1000
EUR 338
Better BCA Protein Assay Kit (Reducing agent compatible)
SK3051 500Assays, 500preps
EUR 114.38
  • Product category: Molecular Biology Kits/Protein - Assays/BSA
Mouse Anti-Sulfa synergist agent monoclonal antibody, clone SSA
CABT-L4234-100ug 100 ug
EUR 533
Mouse Anti-Sulfa synergist agent monoclonal antibody, clone SSA
CABT-L4234-1mg 1 mg
EUR 1313
BCA Protein Assay Kit (Test Tube) - Reducing Agent Compatible
K819-250
EUR 327
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein B (aa 1-139)
VAng-Lsx7513-1mgEcoli 1 mg (E. coli)
EUR 3291
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein B, recombinant protein.
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein B (aa 1-139)
VAng-Lsx7513-500gEcoli 500 µg (E. coli)
EUR 2226
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein B, recombinant protein.
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein B (aa 1-139)
VAng-Lsx7513-50gEcoli 50 µg (E. coli)
EUR 1524
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein B, recombinant protein.
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein C (aa 1-101)
VAng-Lsx7514-1mgEcoli 1 mg (E. coli)
EUR 3630
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein C, recombinant protein.
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein C (aa 1-101)
VAng-Lsx7514-500gEcoli 500 µg (E. coli)
EUR 2460
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein C, recombinant protein.
Recombinant Clostridium Acetobutylicum Chemical-Damaging Agent Resistance Protein C (aa 1-101)
VAng-Lsx7514-50gEcoli 50 µg (E. coli)
EUR 1676
Description: Clostridium Acetobutylicum Chemical-damaging agent resistance protein C, recombinant protein.
DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-.1 100 uL/well(10 mM solution)
EUR 3889
DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-.25 250 uL/well(10 mM solution)
EUR 6905
DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-5 5 mg/well
EUR 9005
pUC18 DNA
G40-300 50µg
EUR 56
pUC18 DNA
G40-305 5x50µg
EUR 147
DNA Antibody
abx023805-02mg 0.2 mg
EUR 648
  • Shipped within 5-10 working days.
DNA Polymerase
ABF5235 100 ug
EUR 438
DNA pol
ABF9055 100 ug
EUR 438
DNA Polymerase
ABD3082 100 ug
EUR 438
DNA antibody
10C-CR6034M1 100 ug
EUR 241
Description: Mouse monoclonal DNA antibody
DNA antibody
10-D20A 500 ug
EUR 493
Description: Mouse monoclonal DNA antibody
DNA antibody
10R-D114b 100 ug
EUR 560
Description: Mouse monoclonal DNA antibody
T7 DNA
310-005 200µg
EUR 82
T7 DNA
310-025 5x200 µg
EUR 225
DNA-fectamine
DNAF001 1ml
EUR 278.81
  • Product category: Biochemicals/Biology Reagents/Transfection Related
DNA-Fect
DF37100-1 1 ml
EUR 349
DNA-Fect293
DF37293-1 1 ml
EUR 291
pBR322 DNA
MSD14 50ug
EUR 152.66
  • Product category: PCR Related/Vectors/Plasmids
Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated
AD-146-B Custom Ask for price
Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled
AD-146-U Custom Ask for price
Mouse Anti-DNA Antibody (DNA) ELISA Kit
abx257816-96tests 96 tests
EUR 746
  • Shipped within 5-12 working days.
DNA Ligase I (DNA Ligase I) Antibody
abx232431-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.
DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N150 500 units
EUR 102
DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N152 5x500 units
EUR 394
DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N154 20x500 units
EUR 1525
Taq DNA polymerase (TQ21) , DNA Aptamer, FITC labeled
AD-146-F Custom Ask for price
Human Neutrophil Elastase (DNA I) , DNA Aptamer, Biotinylated
AD-155-B Custom Ask for price
Human Neutrophil Elastase (DNA I) , DNA Aptamer, unlabeled
AD-155-U Custom Ask for price
Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-YP889065HU
  • EUR 586.00
  • EUR 299.00
  • EUR 2172.00
  • EUR 900.00
  • EUR 1442.00
  • EUR 382.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 57.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombina