Small Non-coding RNAs Are Dysregulated in Huntington’s Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention

Small Non-coding RNAs Are Dysregulated in Huntington's Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention

Huntington’s illness (HD) is a neurodegenerative dysfunction brought on by a trinucleotide repeat enlargement in the huntingtin gene. Transcriptomic dysregulations are well-documented in HD and alterations in small non-coding RNAs (sncRNAs), notably microRNAs (miRNAs), may underpin that phenomenon. Additionally, environmental enrichment (EE), which is used to mannequin a stimulating way of life in pre-clinical analysis, … Read more

Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) have been discovered to play vital roles in the incidence and improvement of cancers. However, the tsRNA profile in gastric cancer is unknown. In this examine, we aimed to determine the worldwide tsRNA profile in plasma from gastric cancer sufferers and elucidate the function of tRF-33-P4R8YP9LON4VDP in gastric cancer. … Read more