Of rodents and ruminants: a comparison of small noncoding RNA requirements in mouse and bovine reproduction

Of rodents and ruminants: a comparison of small noncoding RNA requirements in mouse and bovine reproduction

Ruminants are main producers of meat and milk, thus managing their reproductive potential is a key ingredient in cost-effective, protected, and environment friendly meals manufacturing. Of explicit concern, defects in male germ cells and feminine germ cells might result in considerably lowered reside births relative to fertilization. However, the underlying molecular drivers of these defects … Read more

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Although DNA methylation is one of the best characterised epigenetic mark, the mechanism by which it’s focused to particular areas within the genome stays unclear. Recent research have revealed that local DNA methylation profiles may be dictated by cis-regulatory DNA sequences that primarily function by way of DNA-binding components. Consistent with this discovering, we now … Read more