Small Non-coding RNAs Are Dysregulated in Huntington’s Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention
Huntington’s illness (HD) is a neurodegenerative dysfunction brought on by a trinucleotide repeat enlargement in the huntingtin gene. Transcriptomic dysregulations are well-documented in HD and alterations in small non-coding RNAs (sncRNAs), notably microRNAs (miRNAs), may underpin that phenomenon. Additionally, environmental enrichment (EE), which is used to mannequin a stimulating way of life in pre-clinical analysis, … Read more