[Novel vector preS1-tp fusion protein effectively inhibits hepatitis B virus replication and cccDNA synthesis by mediating hepatitis B virus targeting sequence small interfering RNA]

[Novel vector preS1-tp fusion protein effectively inhibits hepatitis B virus replication and cccDNA synthesis by mediating hepatitis B virus targeting sequence small interfering RNA]

To research the usage of preS1-tp fusion protein as a novel vector to mediate the entry of small interfering RNA (siRNA) targeting the carboxy-terminal nuclear localization sign (NLS) area of hepatitis B virus (HBV) core protein into HBV-infected hepatocytes, and to additional discover the HBV replication inhibition and covalently closed round DNA synthesis. HepG2.2.15 cells … Read more