Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients

Vitamin B12 has been broadly associated to methionine metabolism, which is an integral part for organic methylation reactions, together with DNA methylation. However, the connection between vitamin B12 and DNA methylation continues to be controversial. In addition, there’s rising proof for the affiliation between vitamin B12 and the danger of colorectal most cancers (CRC), though outcomes of this affiliation should be assessed with warning. For this objective, we hypothesized that serum vitamin B12 could possibly be related to international DNA methylation in the CRC context. To take a look at this speculation, we studied the affiliation between international DNA methylation by lengthy interspersed nuclear element-1 (LINE1) in CRC sufferers beneath the 25th percentile of serum vitamin B12.

We discovered that the excessive vitamin B12 group had low LINE1 methylation in each tumor space and peripheral blood mononuclear cells (PBMCs) than the low serum vitamin B12 group. LINE1 methylation ranges had been considerably decrease in tumor space in comparison with the adjoining tumor-free space, solely in the excessive vitamin B12 group. LINE1 methylation in visceral adipose tissue (VAT) and PBMCs had been correlated with tumoral, inflammatory, and insulin metabolism markers. However, the interplay between LINE1 methylation and vitamin B12 ranges was related to neoadjuvant remedy in the regression evaluation solely in males, suggesting a useful relationship. In conclusion, our outcomes reported an inverse affiliation between DNA methylation and vitamin B12 in the CRC context, which means that vitamin B12 could also be implicated in an epigenetic state or mediation in CRC.

Mutations in TERT promoter are established gatekeepers in early hepatocarcinogenesis, however little is thought about different molecular alterations driving this course of. Epigenetic deregulation is a crucial occasion in early malignancies. Thus, we aimed: 1) to research DNA methylation adjustments through the transition from preneoplastic lesions to early HCC (eHCC) and to determine candidate epigenetic gatekeepers, and 2) to evaluate the prognostic potential of methylation adjustments in cirrhotic tissue.

Roles of DEMETER in regulating DNA methylation in vegetative tissues and pathogen resistance

 

DNA methylation is an epigenetic mark vital for genome stability and gene expression. In Arabidopsis thaliana, the 5-methylcytosine DNA glycosylase/demethylase DEMETER (DME) controls energetic DNA demethylation through the reproductive stage; nevertheless, the lethality of loss-of-function dme mutations has made it troublesome to evaluate DME perform in vegetative tissues. Here, we edited DME utilizing CRISPR/Cas9 and created three weak dme mutants that produced just a few viable seeds. We additionally carried out central cell-specific complementation in a powerful dme mutant and mixed this line with mutations in the opposite three Arabidopsis demethylase genes to generate the dme ros1 dml2 dml3 (drdd) quadruple mutant. A DNA methylome evaluation confirmed that DME is required for DNA demethylation at a whole bunch of genomic areas in vegetative tissues.

A transcriptome evaluation of the drdd mutant revealed that DME and the opposite three demethylases are vital for plant responses to biotic and abiotic stresses in vegetative tissues. Despite the restricted function of DME in regulating DNA methylation in vegetative tissues, the dme mutants confirmed elevated susceptibility to bacterial and fungal pathogens. Our examine highlights the vital features of DME in vegetative tissues and supplies invaluable genetic instruments for future investigations of DNA demethylation in crops. This article is protected by copyright. All rights reserved.

 Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients
Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients

 

The affect of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor

 

Introduction: Recently we now have recognized a novel RASSF1C-PIWIL1-piRNA pathway that promotes lung most cancers cell development and migration. PIWI-like proteins work together with piRNAs to type complexes that regulate gene expression on the transcriptional and translational ranges. We have illustrated in earlier work that RASSF1C modulates the expression of the PIWIL1-piRNA gene axis, suggesting the speculation that the RASSF1C-PIWI-piRNA pathway might doubtlessly contribute to lung most cancers stem cell improvement and development, in half, by modulation of gene methylation of each oncogenic and tumor suppressor genes. Therefore, we examined this speculation utilizing a non-small cell lung most cancers (NSCLC) cell mannequin to determine Candidate Differentially Methylated Regions (DMRs) modulated by the RASSF1C-PIWIL1-piRNA pathway.
Materials and strategies: We studied the affect of over-expressing RASSF1C and flattening RASSF1C and PIWIL1 expression on international gene DNA methylation in the NSCLC cell line H1299 utilizing the Reduced Representation Bisulfite Sequencing (RRBS) methodology.
Results: DMRs had been recognized by evaluating DNA methylation profiles of experimental and management cells. Over-expression of RASSF1C and flattening RASSF1C and PIWIL1 modulated DNA methylation of genomic areas; and statistically vital candidate genes residing DMR areas in lung most cancers cells had been recognized, together with oncogenes and tumor suppressors. One of the hypermethylated genes, Gem Interacting Protein (GMIP), shows tumor suppressor properties. GMIP expression attenuates lung most cancers cell migration, and its over-expression is related to longer survival of lung most cancers sufferers.

Global DNA Methylation ELISA Kit (5?-methyl-2?-deoxycytidine Quantitation)

STA-380-5 5 x 96 assays
EUR 2503
Description: The Global DNA Methylation ELISA Kit is a competitive ELISA for the quantitative measurement of 5-methylcytosine (5MedCyd). The unknown 5MedCyd samples or 5MedCyd standards are first added to a 5MedCyd DNA conjugate coated EIA plate. After a brief incubation, an anti-5MedCyd monoclonal antibody is added, followed by an HRP conjugated secondary antibody. The 5MedCyd content in unknown samples is determined by comparison with a predetermined 5MedCyd standard curve.

Methylamp DNA Modification Kit

P-1001 80 Reactions
EUR 347.25
Description: fast delivery possible

EpiQuik Global Histone H3K4 Methylation Assay Kit

P-3017 96 Assays
EUR 889.55
Description: reagents widely cited

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P-3018 96 Assays
EUR 889.55
Description: Ask the seller for details

Methylamp 96 DNA Modification Kit

P-1008 96 Samples
EUR 347.25
Description: reagents widely cited

Methylamp Universal Methylated DNA Kit

P-1011 20 Modifications
EUR 570.55
Description: kits suitable for this type of research

DNA Methylation Detection Kit

K5082100 1 kit
EUR 344

Epizen DNA Methylation Kit

Z4201-050 50 Rxns
EUR 327

Epizen DNA Methylation Kit

Z4201-200 4x50 rxns
EUR 968

EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

P-9005 96 Reactions
EUR 788.05
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P-9008 96 Assays
EUR 788.05
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P-3020 96 Assays
EUR 889.55
Description: fast delivery possible

Methylamp Coupled DNA Isolation & Modification Kit

P-1002 40 Samples
EUR 395.1
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Methylamp One-Step DNA Modification Kit

P-1010 80 Samples
EUR 347.25
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Methylamp Methylated DNA Capture (MeDIP) Kit

P-1015 48 Reactions
EUR 875.05
Description: Ask the seller for details

Methylamp Universal Methylated DNA Preparation Kit

P-1019 40 µg
EUR 347.25
Description: The best epigenetics products

DNA Damage Quantification Kit

55R-1345 25 assays
EUR 844
Description: Assay Kit for Quantification of DNA Damage in the research laboratory

EpiArt DNA Methylation Bisulfite Kit

EM101-01 50 rxn
EUR 241

EpiArt DNA Methylation Bisulfite Kit

EM101-02 200 rxn
EUR 609

EpiArt DNA Methylation Library Kit

NE101-01 24 rxn
EUR 889

EpiArt DNA Methylation Library Kit

NE101-02 96 rxn
EUR 2928

Epizen DNA Methylation-Direct Kit

Z4001-050 50 Rxns
EUR 428

Epizen DNA Methylation-Direct Kit

Z4001-200 4x50 rxns
EUR 1036

Epizen DNA Methylation-Gold Kit

Z4101-050 50 Rxns
EUR 361

Epizen DNA Methylation-Gold Kit

Z4101-200 4x50 rxns
EUR 901

DNA methylation inhibitor, Dichlone

2860-1000
EUR 142

DNA methylation inhibitor, Dichlone

2860-500
EUR 109

Zebularine (DNA methylation inhibitor)

SIH-560-25MG 25 mg
EUR 311
Description: The substance Zebularine is a dna methylation inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml).

Zebularine (DNA methylation inhibitor)

SIH-560-5MG 5 mg
EUR 126
Description: The substance Zebularine is a dna methylation inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml).

ExoELISA-ULTRA Complete Kit (CD63 detection)

EXEL-ULTRA-CD63-1 96 reactions
EUR 713
  • Category: Exosomes

ExoELISA-ULTRA Complete Kit (CD81 detection)

EXEL-ULTRA-CD81-1 96 reactions
EUR 713
  • Category: Exosomes

EpiQuik Global Acetyl Histone H3K9 Quantification Kit (Colorimetric)

P-4010 96 Assays
EUR 788.05
Description: reagents widely cited

EpiQuik Global Acetyl Histone H3K9 Quantification Kit (Fluorometric)

P-4011 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Acetyl Histone H3K14 Quantification Kit (Colorimetric)

P-4012 96 Assays
EUR 788.05
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EpiQuik Global Acetyl Histone H3K14 Quantification Kit (Fluorometric)

P-4013 96 Assays
EUR 788.05
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EpiQuik Global Acetyl Histone H3K18 Quantification Kit (Colorimetric)

P-4014 96 Assays
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P-4015 96 Assays
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P-4016 96 Assays
EUR 788.05
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EpiQuik Global Acetyl Histone H3K23 Quantification Kit (Fluorometric)

P-4017 96 Assays
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EpiQuik Global Acetyl Histone H3K36 Quantification Kit (Colorimetric)

P-4018 96 Assays
EUR 788.05
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P-4019 96 Assays
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EpiQuik Global Acetyl Histone H3K56 Quantification Kit (Colorimetric)

P-4020 96 Assays
EUR 788.05
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P-4021 96 Assays
EUR 788.05
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EpiQuik Global Acetyl Histone H4K5 Quantification Kit (Colorimetric)

P-4022 96 Assays
EUR 788.05
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P-4023 96 Assays
EUR 788.05
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EpiQuik Global Acetyl Histone H4K8 Quantification Kit (Colorimetric)

P-4024 96 Assays
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P-4025 96 Assays
EUR 788.05
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P-4026 96 Assays
EUR 788.05
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P-4027 96 Assays
EUR 788.05
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P-4028 96 Assays
EUR 788.05
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P-4029 96 Assays
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P-4059 96 Assays
EUR 788.05
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DNA Damage Quantification Colorimetric Kit

K2100-25 25 assays
EUR 627

DNA Damage Quantification Colorimetric Kit

K253-25
EUR 610

DNA Quantification Assay Kit (Fluorometric)

K539-200
EUR 262

DNA Quantification Assay Kit (Fluorometric)

K539-2000
EUR 392

FitAmp Circulating DNA Quantification Kit

P-1012 96 Assays
EUR 496.6
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FitAmp General DNA Quantification Kit

P-1020 96 Assays
EUR 300.85
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SuperSense Methylated DNA Quantification Kit

P-1021 96 Assays
EUR 947.55
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EpiQuik Global Di-Methyl Histone H3K4 Quantification Kit (Colorimetric)

P-3022 96 Assays
EUR 788.05
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P-3023 96 Assays
EUR 788.05
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P-3024 96 Assays
EUR 788.05
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P-3025 96 Assays
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P-3026 96 Assays
EUR 788.05
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P-3027 96 Assays
EUR 788.05
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EpiQuik Global Pan-Methyl Histone H3K4 Quantification Kit (Colorimetric)

P-3028 96 Assays
EUR 788.05
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P-3029 96 Assays
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P-3030 96 Assays
EUR 788.05
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P-3031 96 Assays
EUR 788.05
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P-3032 96 Assays
EUR 788.05
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P-3033 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H3K9 Quantification Kit (Colorimetric)

P-3034 96 Assays
EUR 788.05
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P-3035 96 Assays
EUR 788.05
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P-3036 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Pan-Methyl Histone H3K9 Quantification Kit (Fluorometric)

P-3037 96 Assays
EUR 788.05
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P-3038 96 Assays
EUR 788.05
Description: reagents widely cited

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P-3039 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Di-Methyl Histone H3K27 Quantification Kit (Colorimetric)

P-3040 96 Assays
EUR 788.05
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P-3041 96 Assays
EUR 788.05
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P-3042 96 Assays
EUR 788.05
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P-3043 96 Assays
EUR 788.05
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P-3044 96 Assays
EUR 788.05
Description: kits suitable for this type of research

EpiQuik Global Pan-Methyl Histone H3K27 Quantification Kit (Fluorometric)

P-3045 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Mono-Methyl Histone H3K36 Quantification Kit (Colorimetric)

P-3046 96 Assays
EUR 788.05
Description: The best epigenetics products

EpiQuik Global Mono-Methyl Histone H3K36 Quantification Kit (Fluorometric)

P-3047 96 Assays
EUR 788.05
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EpiQuik Global Di-Methyl Histone H3K36 Quantification Kit (Colorimetric)

P-3048 96 Assays
EUR 788.05
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P-3049 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H3K36 Quantification Kit (Colorimetric)

P-3050 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Tri-Methyl Histone H3K36 Quantification Kit (Fluorometric)

P-3051 96 Assays
EUR 788.05
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EpiQuik Global Pan-Methyl Histone H3K36 Quantification Kit (Colorimetric)

P-3052 96 Assays
EUR 788.05
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P-3053 96 Assays
EUR 788.05
Description: kits suitable for this type of research

EpiQuik Global Mono-Methyl Histone H3K79 Quantification Kit (Colorimetric)

P-3054 96 Assays
EUR 788.05
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EpiQuik Global Mono-Methyl Histone H3K79 Quantification Kit (Fluorometric)

P-3055 96 Assays
EUR 788.05
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P-3056 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Di-Methyl Histone H3K79 Quantification Kit (Fluorometric)

P-3057 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H3K79 Quantification Kit (Colorimetric)

P-3058 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H3K79 Quantification Kit (Fluorometric)

P-3059 96 Assays
EUR 788.05
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P-3060 96 Assays
EUR 788.05
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EpiQuik Global Pan-Methyl Histone H3K79 Quantification Kit (Fluorometric)

P-3061 96 Assays
EUR 788.05
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EpiQuik Global Mono-Methyl Histone H4K20 Quantification Kit (Colorimetric)

P-3064 96 Assays
EUR 788.05
Description: kits suitable for this type of research

EpiQuik Global Mono-Methyl Histone H4K20 Quantification Kit (Fluorometric)

P-3065 96 Assays
EUR 788.05
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P-3066 96 Assays
EUR 788.05
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P-3067 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H4K20 Quantification Kit (Colorimetric)

P-3068 96 Assays
EUR 788.05
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EpiQuik Global Tri-Methyl Histone H4K20 Quantification Kit (Fluorometric)

P-3069 96 Assays
EUR 788.05
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EpiQuik Global Pan-Methyl Histone H4K20 Quantification Kit (Colorimetric)

P-3070 96 Assays
EUR 788.05
Description: Ask the seller for details

EpiQuik Global Pan-Methyl Histone H4K20 Quantification Kit (Fluorometric)

P-3071 96 Assays
EUR 788.05
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EpiQuik Global Di-Methyl Histone H4R3 Quantification Kit (Colorimetric)

P-3090 96 Assays
EUR 947.55
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EpiQuik Global Di-Methyl Histone H3R8 Quantification Kit (Colorimetric)

P-3096 96 Assays
EUR 773.55
Description: Ask the seller for details

DNA Methylation/Hydroxymethylation Standard Set

P-1025 2 µg/standard x 3
EUR 570.55
Description: reagents widely cited

Methyflash m6A DNA Methylation ELISA Kit (Colorimetric)

P-9010 96 Assays
EUR 788.05
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MethylFlash Methylated DNA Quantification Kit (Fluorometric)

P-1035 96 Assays
EUR 904.05
Description: fast delivery possible

MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric)

P-1037 96 Assays
EUR 947.55
Description: Ask the seller for details

DNA Methylation Antibody Panel Pack I

C20000
EUR 382.05
Description: Ask the seller for details

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 70
Description: Bioscience Mol Bio; DNA Ladder

Library Quantification DNA Standards (S1-S6)

20-abx098897
  • EUR 620.00
  • EUR 620.00
  • EUR 620.00
  • EUR 620.00
  • 25%, 120 ul
  • 37.5%, 120 ul
  • 50%, 120 ul
  • 62.5%, 120 ul
  • Shipped within 5-10 working days.

VAHTS Library Quantification Kit for IIIumina (DNA Standards)

NQ105 8 rxn
EUR 360

MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)

P-1034 96 Assays
EUR 875.05
Description: kits suitable for this type of research

MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric)

P-1036 96 Assays
EUR 904.05
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EpiQuik DNA Demethylase Activity/Inhibition Assay Ultra Kit

P-3008 96 Assays
EUR 860.55
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Methylamp PCR Enhancer

R-1002 400 Reactions
EUR 154.4
Description: reagents widely cited

Methylamp MS-qPCR Fast Kit

P-1028 200 Reactions
EUR 496.6
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Methylamp RNA Bisulfite Conversion Kit

P-9003 50 Reactions
EUR 300.85
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MethylFlash 5-Formylcytosine (5-fC) DNA Quantification Kit (Colorimetric)

P-1041 96 Assays
EUR 947.55
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EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Colorimetric)

P-6003 96 Assays
EUR 947.55
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EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Fluorometric)

P-6004 96 Assays
EUR 1034.55
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Ultra-Fast 96-Well Plate Plasmid DNA Miniprep Kit

BS92028 2XPlates, 192prep
EUR 212.25
  • Product category: Molecular Biology Kits/DNA - Extraction/Bacteria

Ultra-Fast 96-Well Plate Plasmid DNA Miniprep Kit

BS92029 5XPlates, 480prep
EUR 364.5
  • Product category: Molecular Biology Kits/DNA - Extraction/Bacteria

MethylFlash Global DNA Hydroxymethylation (5-hmC) ELISA Easy Kit (Colorimetric)

P-1032 96 reactions
EUR 889.55
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Acetylcholine Quantification Kit

55R-1457 100 assays
EUR 774
Description: Acetylcholine Quantification Kit for use in the research laboratory

Triglyceride Quantification Kit

55R-1464 100 assays
EUR 860
Description: Triglyceride Quantification Kit for use in the research laboratory

mCherry Quantification Kit

K971-100
EUR 398

Methylamp Whole Cell Bisulfite Modification Kit

P-1016 80 Samples
EUR 496.6
Description: The best epigenetics products

Taq DNA Polymerase, Ultra Pure, 5 units/ul

T2016-001 1000 units
EUR 165

Taq DNA Polymerase, Ultra Pure, 5 units/ul

T2016-005 5000 units
EUR 300

Taq DNA Polymerase, Ultra Pure, 5 units/ul

T2016-010 10,000 units
EUR 583

Taq DNA Polymerase, Ultra Pure, 5 units/ul

T2016-100 100,000 units
EUR 2885

QuantiSir Specific Gene Knockdown Quantification Kit For DNA Damage/Repair - XRCC4

P-5003 96 Assays
EUR 788.05
Description: reagents widely cited

Bradford Protein Quantification Kit

E111-01 500 rxn
EUR 132

Bradford Protein Quantification Kit

E111-02 1000 rxn
EUR 157

BCA Protein Quantification Kit

E112-01 250 rxn
EUR 132

BCA Protein Quantification Kit

E112-02 500 rxn
EUR 152

HDL/LDL Quantification Kit

55R-1456 100 assays
EUR 912
Description: HDL/LDL Quantification Kit for use in the research laboratory

Lipid Quantification Kit (Fluorometric)

STA-617 100 assays
EUR 531
Description: The Lipid Quantification Kit (Fluorometric) uses a fluorometric detection system to quantify neutral lipids in a convenient 96-well microplate reader. The kit includes sufficient reagents for 100 assays.

Retrovirus qPCR Quantification Kit

K1472-100 100 Rxns Ask for price

Lentivirus qPCR Quantification Kit

K1471-100 100 Rxns
EUR 298

EpiQuik MeDIP Ultra Kit

P-1052 48 Reactions
EUR 1005.55
Description: fast delivery possible

Pico488 dsDNA quantification kit, 200

B1102 200 assays
EUR 319
Conclusions: The RASSF1C-PIWI-piRNA pathway modulates key oncogenes and tumor suppressor genes. GMIP is hypermethylated by this pathway and has tumor suppressor properties.