Long non-coding RNA small nucleolar RNA host gene 1 knockdown suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating microRNA-424-5p/FGF2 in vitro

The intention of the current examine was to make clear the impact of lengthy non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the proliferation, migration and invasion of osteosarcoma (OS) cells and to discover the potential underlying mechanisms. The expression ranges of SNHG1, microRNA (miR)-424-5p and fibroblast progress issue 2 (FGF2) in OS tissues and cells have been detected utilizing reverse transcription-quantitative polymerase chain response. OS cell proliferation, migration and invasion have been analysed by MTT, wound therapeutic and Transwell invasion assays, respectively.

The concentrating on relationships between SNHG1 and miR-424-5p, in addition to between miR-424-5p and FGF2, have been confirmed utilizing RNA-binding protein immunoprecipitation and/or dual-luciferase reporter gene assays. The outcomes demonstrated that the expression ranges of SNHG1 and FGF2 have been upregulated, whereas the expression of miR-424-5p was downregulated in OS tissues and cells. The silencing of SNHG1 considerably inhibited the proliferation, migration and invasion of OS cells. Additionally, FGF2 was proven to be a goal of miR-424-5p, which in flip, was a goal of SNHG1. miR-424-5p silencing and FGF2 overexpression each reversed the suppressive results of SNHG1 knockdown on the proliferation, migration and invasion of OS cells.

Viral interfering RNA (viRNA) has been recognized from a number of viral genomes by way of straight deep RNA sequencing of the virus-infected cells, together with zika virus (ZIKV). Once produced by endoribonuclease Dicer, viRNAs are loaded onto the Argonaute (AGO) household proteins of the RNA-induced silencing complexes (RISCs) to pair with their RNA targets and provoke the cleavage of goal genes. However, the identities of useful ZIKV viRNAs and their viral RNA targets stay largely unknown. Thus, the silencing of SNHG1 could inhibit the proliferation, migration and invasion of OS cells by regulating the miR-424-5p/FGF2 axis.

Our latest examine has proven that ZIKV capsid protein interacted with Dicer and antagonized its endoribonuclease exercise, which requires its histidine residue at the 41^st amino acid. Accordingly, the engineered ZIKV-H41R loss-of-function (LOF) mutant virus not suppresses Dicer enzymatic exercise nor inhibits miRNA biogenesis in NSCs. By combining AGO-associated RNA sequencing, deep sequencing evaluation in ZIKV-infected human neural stem cells (NSCs), and miRanda goal scanning, we outlined 29 ZIKV derived viRNA profiles in NSCs, and established a posh interplay community between the viRNAs and their viral targets. ‘

More importantly, we discovered that viRNA manufacturing from the ZIKV mRNA relies on Dicer operate and is a limiting issue for ZIKV virulence in NSCs. As a consequence, a lot greater ranges of viRNAs generated from the ZIKV-H41R virus-infected NSCs. Therefore, our mapping of viRNAs to their RNA targets paves a option to additional examine how viRNAs play the function in anti-viral mechanisms, and maybe different unknown organic features.

Stress resets ancestral heritable small RNA responses

Transgenerational inheritance of small RNAs challenges primary ideas of heredity. In C. elegans nematodes, small RNAs are transmitted throughout generations to ascertain a transgenerational reminiscence hint of ancestral environments and distinguish self-genes from non-self-elements. Carryover of aberrant heritable small RNA responses was proven to be maladaptive and to result in sterility. Here we present that numerous varieties of stress (hunger, excessive temperatures, and excessive osmolarity) induce resetting of ancestral small RNA responses and a genome-wide discount in heritable small RNA ranges.

We discovered that mutants which can be faulty in numerous stress pathways exhibit irregular RNAi inheritance dynamics even in the absence of stress. Moreover, we found that resetting of ancestral RNAi responses is particularly orchestrated by elements that operate in the p38 MAPK pathway and the transcription issue SKN-1/Nrf2. Stress-dependent termination of small RNA inheritance may defend from run-on of environment-irrelevant heritable gene regulation. In conclusion, AGT siRNA exerts renoprotection in the 5/sixth Nx mannequin in a blood pressure-independent method. This depends on the suppression of renal Ang II formation from liver-derived AGT. Consequently, AGT siRNA could show useful in human power kidney illness.

Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease

Small interfering RNA (siRNA) concentrating on liver angiotensinogen (AGT) lowers blood stress, however its effectiveness in hypertensive power kidney illness is unknown. Considering that the kidney could generate its personal AGT, we assessed the effectiveness of liver-targeted AGT siRNA in the 5/sixth Nx (5/sixth nephrectomy) rat-a hypertensive power kidney illness mannequin. Five weeks after 5/sixth Nx (baseline), rats have been subjected to automobile, AGT siRNA, AGT siRNA+losartan, losartan, or losartan+captopril. Baseline imply arterial stress was 160±6 mm Hg. Over the course of four weeks, imply arterial stress elevated additional by ≈15 mm Hg throughout automobile remedy. This rise was prevented by AGT siRNA.

Total RNA from Rat Normal Tissue: Liver
R1434149-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Colon
R1236090Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Kidney
R1236142Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Lung
R1236152Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Diaphragm
R1236169Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Pancreas
R1236188Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Rectum
R1236206Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Spleen
R1236246Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Liver
R1235149-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Small Intestine
R1236226Lcs-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Liver
R1334149-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Liver
R1234149-50	Biochain	50 ug	EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Rhesus) Normal Tissue: Liver
R1534149-50	Biochain	50 ug	EUR 194
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Liver
R1534149-Cy	Biochain	50 ug	EUR 194
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Total RNA - Human Adult Normal Tissue: Liver
R2234149	Biochain	1 ug	EUR 628
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Plant Total RNA Mini Kit (100prep)
FAPRK-001-1	Favorgen	100 preps	EUR 216

Plant Total RNA Maxi Kit (24prep)
FAPRK-002-1	Favorgen	24 preps	EUR 317

Tissue Total RNA Mini Kit (100prep)
FATRK-001-1	Favorgen	100 preps	EUR 216

Tissue Total RNA Maxi Kit (24prep)
FATRK-003-1	Favorgen	24 preps	EUR 317

Total Protein from Liver Cirrhosis: Liver
P1236149Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Normal Lymphocyte Cell Line
R1254148-1	Biochain	100 ug	EUR 228
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Liver: Left Lobe
R1234150-50	Biochain	50 ug	EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Liver: Right Lobe
R1234151-50	Biochain	50 ug	EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL	Cell Biolabs	96 assays	EUR 572

Blood/Cultured Cell Total RNA Mini Kit (100prep)
FABRK-001-1	Favorgen	100 preps	EUR 216

Blood/Cultured Cell Total RNA Maxi Kit (24prep)
FABRK-003-1	Favorgen	24 preps	EUR 317

RNA isolater Total RNA Extraction Reagent
R401-01	Vazyme	100 ml	EUR 133

Green RNA Lysis Kit 50
GREENE1-RNA	Next Advance	50pack	EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250
GREENE5-RNA	Next Advance	250pack	EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Navy RNA Lysis Kit 50
NAVYE1-RNA	Next Advance	50pack	EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250
NAVYE5-RNA	Next Advance	250pack	EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Pink RNA Lysis Kit 50
PINKE1-RNA	Next Advance	50pack	EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250
PINKE5-RNA	Next Advance	250pack	EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 50
REDE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250
REDE5-RNA	Next Advance	250pack	EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50
YELLOWE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250
YELLOWE5-RNA	Next Advance	250pack	EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Total RNA from Human Adult Normal Tissue: Liver, Ambient temperature shipping
ATR1234149-50	Biochain	50 ug	EUR 190
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue 5 Donor Pool: Liver
R1234149-P	Biochain	50 ug	EUR 328
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA Extraction Kit
K2014005	Biochain	1 kit	EUR 344
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA Isolation Kit
P-9100	EpiGentek	50 samples	EUR 347.25
Description: The best epigenetics products

Total Protein from Lupus: Liver
P1236149Lup	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

5E GREEN RNA Lysis Kit 100
GREEN5E100-RNA	Next Advance	100pack	EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20
GREEN5E20-RNA	Next Advance	20pack	EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50
GREENR1-RNA	Next Advance	50pack	EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250
GREENR5-RNA	Next Advance	250pack	EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E Navy RNA Lysis Kit 100
NAVY5E100-RNA	Next Advance	100pack	EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20
NAVY5E20-RNA	Next Advance	20pack	EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50
NAVYR1-RNA	Next Advance	50pack	EUR 202
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 250
NAVYR5-RNA	Next Advance	250pack	EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E PINK RNA Lysis Kit 100
PINK5E100-RNA	Next Advance	100pack	EUR 380
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20
PINK5E20-RNA	Next Advance	20pack	EUR 136
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50
PINKR1-RNA	Next Advance	50pack	EUR 181
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250
PINKR5-RNA	Next Advance	250pack	EUR 576
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100
RED5E100-RNA	Next Advance	100pack	EUR 429
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20
RED5E20-RNA	Next Advance	20pack	EUR 148
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50
REDR1-RNA	Next Advance	50pack	EUR 195
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250
REDR5-RNA	Next Advance	250pack	EUR 638
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50
YELLOWR1-RNA	Next Advance	50pack	EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250
YELLOWR5-RNA	Next Advance	250pack	EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Liver Cancer Exosome RNA
P241-LV	101Bio	NULL	EUR 0

Plant Total RNA Mini Kit (100prep), for Woody Plant
FAPRK-003-1	Favorgen	100 preps	EUR 223

FFPE and Frozen Matching Pair Total RNA: Human Adult Normal Tissue: Liver
R8234149-FP	Biochain	2x1 ug	EUR 1361
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Liver
R8235149-PM-10	Biochain	2x10 ug	EUR 650
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Liver
R8235149-PP-10	Biochain	2x10 ug	EUR 439
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Normal Lymphocyte Cell Line, Ambient temperature shipping
ATR1254148-1	Biochain	100 ug	EUR 221
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL-5	Cell Biolabs	5 x 96 assays	EUR 2283

96-well Total RNA Kit (1 plates)
FATRE-96001	Favorgen	1 prep	EUR 194

Total RNA from Rat Normal Tissue: Adipose
R1434003-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Bladder
R1434010-50	Biochain	50 ug	EUR 303
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Brain
R1434035-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Colon
R1434090-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Heart
R1434122-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Kidney
R1434142-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Lung
R1434152-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Ovary
R1434183-50	Biochain	50 ug	EUR 296
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Pancreas
R1434188-50	Biochain	50 ug	EUR 296
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Placenta
R1434200-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Rectum
R1434206-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Spleen
R1434246-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Stomach
R1434248-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Testis
R1434260-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Thymus
R1434264-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Liver Cirrhosis: Adrenal
P1236004Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Appendix
P1236006Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Brain
P1236035Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Colon
P1236090Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Esophagus
P1236106Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Gallbladder
P1236118Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Heart
P1236122Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Kidney
P1236142Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Lung
P1236152Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Diaphragm
P1236169Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Pancreas
P1236188Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Prostate
P1236201Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Rectum
P1236206Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Skin
P1236218Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Spleen
P1236246Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Testis
P1236260Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Thyroid
P1236265Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Immortalized Human Total Liver Cell Population
T0581	ABM	1x106 cells / 1.0 ml	Ask for price

Total RNA Isolation Kit II
FATRS--001	Favorgen	100 preps	EUR 308

Total RNA Isolation Kit II
FATRS--050	Favorgen	50 preps	EUR 216

Total RNA ExtractionMini KitAnimal Tissues
FYG301-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA Isolation Kit (Tissue)
P-9102	EpiGentek	50 samples	EUR 347.25
Description: reagents widely cited

Total RNA Isolation Kit (Plant)
P-9104	EpiGentek	50 samples	EUR 347.25
Description: kits suitable for this type of research

Total RNA from Lupus: Colon
R1236090Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart
R1236122Hd-2	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Kidney
R1236142Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Lung
R1236152Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Pancreas
R1236188Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Spleen
R1236246Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Stomach
R1236248Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Uterus
R1236274Lup-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

AnaPrep Total RNA Extraction Kit
Z1322015	Biochain	1 kit (48 extractions) Including all required plastic disposables	EUR 308
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

Anti-Liver Carboxylesterase 1/CES1 Antibody
A01741-1	BosterBio	100ug/vial	EUR 334

Total RNA from Rat Normal Tissue: Brain, cerebellum
R1434039-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Skeletal Muscle
R1434171-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Small Intestine
R1434226-50	Biochain	50 ug	EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Tissue: Liver
P1235149	Biochain	1 mg	EUR 320
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Diabetic Tissue: Liver
P1236149Dia	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Lupus: Liver: Left Lobe
P1236150Lup	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Lupus: Liver: Right Lobe
P1236151Lup	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Lymph Node
P1236161Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Small Intestine
P1236226Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Liver Cirrhosis: Spinal Cord
P1236234Lcs	Biochain	1 mg	EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Mouse Normal Tissue: Liver
P1334149	Biochain	1 mg	EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Plant Total RNA Mini Kit (50prep)
FAPRK-001	Favorgen	50 preps	EUR 165

Plant Total RNA Mini Kit (300prep)
FAPRK-001-2	Favorgen	300 preps	EUR 404

Losartan lowered imply arterial stress by 37±6 mm Hg and elevated plasma Ang (angiotensin) II. Both AGT siRNA and captopril suppressed these results of losartan, suggesting that its blood pressure-lowering impact relied on stimulation of vasodilator Ang II kind 2 receptors by excessive Ang II ranges. Proteinuria and cardiac hypertrophy elevated with automobile, and these will increase have been comparably abrogated by all remedies. No intervention improved glomerular filtration charge, whereas siRNA and losartan equally diminished glomerulosclerosis. AGT siRNA±losartan lowered plasma AGT by >95%, and this was accompanied by virtually full elimination of Ang II in kidney and coronary heart, with out lowering renal AGT mRNA. Multiple linear regression confirmed each imply arterial stress and renal Ang II as impartial determinants of proteinuria.