Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

by

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) have been discovered to play vital roles in the incidence and improvement of cancers. However, the tsRNA profile in gastric cancer is unknown. In this examine, we aimed to determine the worldwide tsRNA profile in plasma from gastric cancer sufferers and elucidate the function of tRF-33-P4R8YP9LON4VDP in gastric cancer. Differentially expressed tsRNAs in the plasma of gastric cancer sufferers and wholesome controls had been investigated utilizing RNA sequencing.

The expression ranges of tRF-33-P4R8YP9LON4VDP in the plasma of gastric cancer sufferers, wholesome controls and gastric cancer cell strains had been first detected by quantitative reverse transcription-polymerase chain response. The results of tRF-33-P4R8YP9LON4VDP overexpression or downregulation in gastric cancer cells on proliferation, migration, apoptosis, and cell cycle had been analyzed utilizing the Cell Counting Kit-8, scratch assay, Transwell assay, and circulation cytometry, respectively. There had been 21 upregulated and 46 downregulated tsRNAs discovered in plasma from gastric cancer sufferers.

Glioblastoma multiforme (GBM) is one of the worst mind tumors arising from glial cells, inflicting many deaths yearly. Surgery, chemotherapy, radiotherapy and immunotherapy are used for GBM therapy. However, GBM continues to be an incurable illness, and new approaches are required for its profitable therapy. Because mutations and amplifications occurring in a number of genes are answerable for the development and aggressive habits of GBM cells, genetic approaches are of nice significance in its therapy. Small interfering RNA (siRNA) is a new rising software to silence the genes answerable for illness development, significantly cancer. SiRNA can be utilized for GBM therapy by down-regulating genes such as VEGF, STAT3, ELTD1 or EGFR.

Furthermore, the use of siRNA can promote the chemosensitivity of GBM cells. However, the effectivity of siRNA in GBM is restricted by its degradation by enzymes, and its off-targeting results. SiRNA-loaded carriers, particularly nanovehicles which are ligand-functionalized by CXCR4 or angiopep-2, can be utilized for the safety and focused supply of siRNA. Nanostructures can present a platform for co-delivery of siRNA plus anti-tumor medicine as one other profit. The ready nanovehicles needs to be steady and biocompatible in order to be examined in human research.

Long non-coding RNA NEAT1 regulates ferroptosis sensitivity in non-small-cell lung cancer

Ferroptosis is brought on by iron-dependent lipid peroxide accumulation, the sensitivity of which is perhaps regulated by acyl-CoA synthetase lengthy chain member of the family 4 (ACSL4). Non-small-cell lung cancer (NSCLC) can resist oxidative stress and scale back the sensitivity of tumor cells to ferroptosis by altering the expression of some proteins. Mechanisms involving ferroptosis sensitivity in NSCLC aren’t absolutely understood. NEAT1 regulates ferroptosis and ferroptosis sensitivity, with the latter relying on ACSL4, suggesting that focusing on NEAT1 or ACSL4 could also be a viable therapeutic strategy to the therapy of NSCLC.
A dual-luciferase reporter assay was used to verify a focusing on relationship between lengthy non-coding (lnc)RNA NEAT1 and ACSL4. Overexpression and silencing assays of NEAT1 operate had been used to find out its roles in cell loss of life (by TUNEL staining) and lipid peroxidation (by malondialdehyde ranges). Expression of ferroptosis-related proteins (SLCA11, GPX4, and TFR4) was evaluated by western blot in NSCLC cells handled or not with the ferroptosis inducer erastin. In this mini-review, the small molecules divided into 4 sorts are expounded which centered primarily on their structural options and organic actions.
Extensive proof signifies that RNA G-quadruplexes have related to some vital mobile occasions. Investigation of RNA G-quadruplexes is thus very important to revealing their biofunctions. Several small molecules have been developed to focus on RNA G-quadruplexes to this point. Some of the small molecules confirmed considerably light-up fluorescence alerts upon binding to RNA G-quadruplexes, whereas some of them regulated the biofunctions of RNA G-quadruplexes.  Moreover, we raised the present challenges and promising prospects. This mini-review may contribute to exploiting extra subtle small molecules focusing on RNA G-quadruplexes with excessive specificity based mostly on the reported chemical structural options.
Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor

Plant ARGONAUTE Protein Immunopurification for Pathogen Cross Kingdom Small RNA Analysis

Over the final decade, it has been seen that microbial pathogens and pests ship small RNA (sRNA) effectors into their host crops to govern plant physiology and immunity for an infection, identified as cross kingdom RNA interference. In this course of, fungal and oomycete parasite sRNAs hijack the plant ARGONAUTE (AGO)/RNA-induced silencing advanced to post-transcriptionally silence host goal genes. We hereby describe the methodological particulars of how we recovered cross kingdom sRNA effectors of the oomycete pathogen Hyaloperonospora arabidopsidis throughout an infection of its host plant Arabidopsis thaliana.

This Bio-protocol accommodates two elements: first, a detailed description on the process of plant AGO/sRNA co-immunopurification and sRNA restoration for Illumina excessive throughput sequencing evaluation. Second, we clarify how you can carry out bioinformatics evaluation of sRNA sequence reads utilizing a Galaxy server. In precept, this protocol is appropriate to analyze AGO-bound sRNAs from various host crops and plant-interacting (micro)organisms. RNA-based therapeutics have emerged as one of essentially the most highly effective therapeutic choices used for the modulation of gene/protein expression and gene enhancing with the potential to deal with neurodegenerative ailments.

Brain Dissociation System 5 (Cerebral cortex), Mouse and Rat
4-20225 ea Ask for price

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL 96 assays
EUR 572

cDNA from Human Adult Normal Tissue: Brain: Cerebral Cortex
C1234042-10 10 reactions
EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Cerebral Cortex
C1534042-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Frozen Tissue Section - Human Adult Normal: Brain: Cerebral Cortex
T1234042 5 slides
EUR 349
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebral Cortex
T2234042 5 slides
EUR 211
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Green RNA Lysis Kit 50
GREENE1-RNA 50pack
EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250
GREENE5-RNA 250pack
EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Pink RNA Lysis Kit 50
PINKE1-RNA 50pack
EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250
PINKE5-RNA 250pack
EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Navy RNA Lysis Kit 50
NAVYE1-RNA 50pack
EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250
NAVYE5-RNA 250pack
EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Red RNA Lysis Kit 50
REDE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250
REDE5-RNA 250pack
EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50
YELLOWE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250
YELLOWE5-RNA 250pack
EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

RNA isolater Total RNA Extraction Reagent
R401-01 100 ml
EUR 133

Total RNA Extraction Kit
K2014005 1 kit
EUR 344
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA Isolation Kit
P-9100 50 samples
EUR 347.25
Description: The best epigenetics products

Membrane Protein from Human Adult Normal Tissue: Brain: Cerebral Cortex
P3234042 0.1 mg
EUR 285
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Cortex
PC35102 1 Cortical Pair
EUR 396

Cortex
PC35110 4 million cells
EUR 866

Cortex
PC35112 4 Cortical Pair
EUR 1348

Cortex
PC36111 4 Cortical Pair
EUR 1348

5E GREEN RNA Lysis Kit 100
GREEN5E100-RNA 100pack
EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20
GREEN5E20-RNA 20pack
EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50
GREENR1-RNA 50pack
EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250
GREENR5-RNA 250pack
EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E PINK RNA Lysis Kit 100
PINK5E100-RNA 100pack
EUR 380
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20
PINK5E20-RNA 20pack
EUR 136
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50
PINKR1-RNA 50pack
EUR 181
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250
PINKR5-RNA 250pack
EUR 576
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Navy RINO RNA Lysis Kit 250
NAVYR5-RNA 250pack
EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 100
NAVY5E100-RNA 100pack
EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20
NAVY5E20-RNA 20pack
EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50
NAVYR1-RNA 50pack
EUR 202
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E RED RNA Lysis Kit 100
RED5E100-RNA 100pack
EUR 429
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20
RED5E20-RNA 20pack
EUR 148
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50
REDR1-RNA 50pack
EUR 195
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250
REDR5-RNA 250pack
EUR 638
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50
YELLOWR1-RNA 50pack
EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250
YELLOWR5-RNA 250pack
EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL-5 5 x 96 assays
EUR 2283

CD1 antibody
10R-CD1aPGp 500 ug
EUR 565
Description: Mouse monoclonal CD1 antibody

Mouse CD1 ELISA Kit
EMC0864 96Tests
EUR 521

T-cell Surface Glycoprotein CD1 (CD1) Antibody
abx413840-01mg 0.1 mg
EUR 453

Total RNA from Mouse Normal Tissue: Adipose
R1334003-50 50 ug
EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Bladder
R1334010-50 50 ug
EUR 303
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Brain
R1334035-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Colon
R1334090-50 50 ug
EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Heart
R1334122-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Kidney
R1334142-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Liver
R1334149-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Lung
R1334152-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Pancreas
R1334188-50 50 ug
EUR 341
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Placenta
R1334200-50 50 ug
EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Rectum
R1334206-50 50 ug
EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Spleen
R1334246-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Stomach
R1334248-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Testis
R1334260-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

AnaPrep Total RNA Extraction Kit
Z1322015 1 kit (48 extractions) Including all required plastic disposables
EUR 308
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

Total RNA from Lupus: Colon
R1236090Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart
R1236122Hd-2 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Kidney
R1236142Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Liver
R1236149Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Lung
R1236152Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Pancreas
R1236188Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Spleen
R1236246Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Stomach
R1236248Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Uterus
R1236274Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA Isolation Kit II
FATRS--001 100 preps
EUR 308

Total RNA Isolation Kit II
FATRS--050 50 preps
EUR 216

Total RNA Isolation Kit (Tissue)
P-9102 50 samples
EUR 347.25
Description: reagents widely cited

Total RNA Isolation Kit (Plant)
P-9104 50 samples
EUR 347.25
Description: kits suitable for this type of research

Total RNA ExtractionMini KitAnimal Tissues
FYG301-50P 50 Preps Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-100P 100 Preps Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-300P 300 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-100P 100 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-300P 300 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-50P 50 Preps Ask for price

Prefrontal Cortex
PC35124 Prefrontal Cortex
EUR 396

CD1 antibody (biotin)
61R-CD1aPGBT 500 ug
EUR 543
Description: Mouse monoclonal CD1 antibody (biotin)

CD1 antibody (FITC)
61R-CD1aPGFT 500 ug
EUR 565
Description: Mouse monoclonal CD1 antibody (FITC)

CD1 antibody (PE)
61R-CD1aPGPE 100 ug
EUR 349
Description: Mouse monoclonal CD1 antibody (PE)

anti-CD1 (9H6)
LF-MA20361 100 ug
EUR 354
Description: Mouse monoclonal to CD1

CD1 Monoclonal Antibody
ABM40068-003ml 0.03ml
EUR 158
Description: A monoclonal antibody for detection of CD1 from Human, Mouse, Rat. This CD1 antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

CD1 Monoclonal Antibody
ABM40068-01ml 0.1ml
EUR 289
Description: A monoclonal antibody for detection of CD1 from Human, Mouse, Rat. This CD1 antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

CD1 Monoclonal Antibody
ABM40068-02ml 0.2ml
EUR 414
Description: A monoclonal antibody for detection of CD1 from Human, Mouse, Rat. This CD1 antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Anti-CD1 antibody
STJ96970 200 µl
EUR 197
Description: CD1 is a protein encoded by the CD1A gene which is approximately 37 kDa. CD1 is localised to the cell membrane. It is involved in hematopoietic cell lineage, dendritic cells developmental lineage pathway and the innate immune system. This protein falls under the CD1 family of transmembrane glycoproteins which form heterodimers with beta-2-microglobulin. CD1 mediates the presentation of primarily lipid and glycolipid antigens to T-cells. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1 is expressed in the blood, skin, heart and lymph nodes. Mutations in the CD1A gene may result in myofibroma. STJ96970 was developed from clone 9H6 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CD1 proteins.

Anti-CD1 antibody
STJ16100020 100 µg
EUR 354

CD1 Monoclonal Antibody
EM1068-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against CD1 from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

CD1 Monoclonal Antibody
EM1068-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against CD1 from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Total RNA from Mouse Normal Tissue: Whole Eye
R1334108-50 50 ug
EUR 296
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Skeletal Muscle
R1334171-50 50 ug
EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Small Intestine
R1334226-50 50 ug
EUR 214
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Brain
R1236035Alz-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Pons
R1236071Alz-10 10 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Colon
R1236090Dia-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Colon
R1236090Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Esophagus
R1236106Dia-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Interventricular Septum
R1236130Hd-2 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Kidney
R1236142Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Liver
R1236149Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Lung
R1236152Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Diaphragm
R1236169Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Pancreas
R1236188Dia-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Pancreas
R1236188Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Rectum
R1236206Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Small Intestine
R1236226Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Spleen
R1236246Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Stomach
R1236248Dia-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Broad Range Total RNA Isolation Kit
K1341050 1 kit
EUR 266
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Plant Total RNA Mini Kit (50prep)
FAPRK-001 50 preps
EUR 165

However, the supply of nucleic acids to the central nervous system (CNS), in specific by the systemic route, stays a main hurdle. This assessment will concentrate on the methods for systemic supply of therapeutic nucleic acids designed to beat these boundaries. Pathways and mechanisms of transport throughout the blood-brain barrier which might be exploited for supply are described, focusing in specific on smaller nucleic acids together with antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).