Placental lipids transfer is essential for optimal fetal development, and alterations of these mechanisms could lead to a higher risk of adverse birth outcomes. Low-density lipoprotein receptor (LDLR), LDL receptor-related protein 1 (LRP1), and scavenger receptor class B type 1 (SCARB1) genes are encoding lipoprotein receptors expressed in the placenta where they participate in cholesterol exchange from maternal to fetal circulation.
The aim of this study was thus to investigate the association between maternal lipid changes occurring in pregnancy, placental DNA methylation (DNAm) variations at LDLR, LRP1, and SCARB1 gene loci, and newborn’s anthropometric profile at birth. Sixty-nine normoglycemic women were followed from the first trimester of pregnancy until delivery.
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Abfrontier |
50 ul |
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abx071022-100U |
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KD Plus DNA Polymerase Enzyme |
abx071022-1200U |
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1200 U |
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KD Plus DNA Polymerase Enzyme |
abx071022-200U |
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200 U |
EUR 314 |
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Guinea Pig IS ELISA Kit |
EGI0046 |
Abclonal |
96Tests |
EUR 521 |
Anti-200 kD Neurofilament Heavy (2E8) |
YF-MA14405 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to 200 kD Neurofilament Heavy |
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PA63-R-500 |
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500 ug |
EUR 1937 |
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Purified Recombinant Anthrax Protective Antigen (83 kD) |
PA83-R-1000 |
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1000 ug |
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Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75 ng/ml |
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200 ug
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200 U |
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ELI-08786Ra |
Lifescience Market |
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AV-9140-100 |
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1 mg |
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Purified Recombinant Anthrax Protective Antigen (PA83 kD) protein control for WB |
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100 ul |
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PA63-C |
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Placental DNAm was quantified at 43 Cytosine-phosphate-Guanines (CpGs) at LDLR, LRP1, and SCARB1 gene loci using pyrosequencing: 4 CpGs were retained for further analysis. Maternal clinical data were collected at each trimester of pregnancy. Newborns’ data were collected from medical records. Statistical models included minimally newborn sex and gestational and maternal age.
Maternal total cholesterol changes during pregnancy (ΔT3-T1) were correlated with DNAm variations at LDLR (r = -0.32, p = 0.01) and LRP1 (r = 0.34, p = 0.007). DNAm at these loci was also correlated with newborns’ cord blood triglyceride and leptin levels. Mediation analysis supports a causal relationship between maternal cholesterol changes, DNAm levels at LRP1 locus, and cord blood leptin concentration (pmediation = 0.02).
These results suggest that LRP1 DNAm link maternal blood cholesterol changes in pregnancy and offspring adiposity at birth, which provide support for a better follow-up of blood lipids in pregnancy.