DNA methylation at LRP1 gene locus mediates the association between maternal total cholesterol changes in pregnancy and cord blood leptin levels.

Placental lipids transfer is essential for optimal fetal development, and alterations of these mechanisms could lead to a higher risk of adverse birth outcomes. Low-density lipoprotein receptor (LDLR), LDL receptor-related protein 1 (LRP1), and scavenger receptor class B type 1 (SCARB1) genes are encoding lipoprotein receptors expressed in the placenta where they participate in cholesterol exchange from maternal to fetal circulation.

The aim of this study was thus to investigate the association between maternal lipid changes occurring in pregnancy, placental DNA methylation (DNAm) variations at LDLR, LRP1, and SCARB1 gene loci, and newborn’s anthropometric profile at birth. Sixty-nine normoglycemic women were followed from the first trimester of pregnancy until delivery.

IS ELISA KIT|Human
EF007501 96 Tests
EUR 689

Sheep IS ELISA Kit
ESI0046 96Tests
EUR 521

Mouse IS ELISA Kit
EMI0046 96Tests
EUR 521

Monkey IS ELISA Kit
EMKI0046 96Tests
EUR 521

Porcine IS ELISA Kit
EPI0046 96Tests
EUR 521

Rat IS ELISA Kit
ERI0046 96Tests
EUR 521

Rabbit IS ELISA Kit
ERTI0046 96Tests
EUR 521

Anserini IS ELISA Kit
EAI0046 96Tests
EUR 521

Goat IS ELISA Kit
EGTI0046 96Tests
EUR 521

Canine IS ELISA Kit
ECI0046 96Tests
EUR 521

Chicken IS ELISA Kit
ECKI0046 96Tests
EUR 521

Human IS ELISA Kit
EHI0046 96Tests
EUR 521

Bovine IS ELISA Kit
EBI0046 96Tests
EUR 521

anti-200 kD Neurofilament Heavy
YF-PA24227 50 ul
EUR 334
Description: Mouse polyclonal to 200 kD Neurofilament Heavy

KD Plus DNA Polymerase Enzyme
abx071022-100U 100 U
EUR 244

KD Plus DNA Polymerase Enzyme
abx071022-1200U 1200 U
EUR 899

KD Plus DNA Polymerase Enzyme
abx071022-200U 200 U
EUR 314

Guinea Pig IS ELISA Kit
EGI0046 96Tests
EUR 521

Anti-200 kD Neurofilament Heavy (2E8)
YF-MA14405 100 ug
EUR 363
Description: Mouse monoclonal to 200 kD Neurofilament Heavy

Recombinant Salmonella typhi pagC [His], 24 kD
DAGA-247 1 mg
EUR 2001

Cytokeratin 19 (40 kD); Clone BA 17
A00094 6 ml
EUR 220

Cytokeratin 19 (40 kD); Clone BA 17
A00094.0025 25 ml
EUR 514

Cytokeratin 19 (40 kD); Clone BA 17
A20094 2 ml
EUR 136

Purified Recombinant Anthrax Protective Antigen (63 kD)
PA63-R-500 500 ug
EUR 1937

Purified Recombinant Anthrax Protective Antigen (83 kD)
PA83-R 100 ug
EUR 651

Purified Recombinant Anthrax Protective Antigen (83 kD)
PA83-R-1000 1000 ug
EUR 2425

In-situ adapter for use with T5000-96
T5000-A-IS 1 PC
EUR 2550.59

Human Serum Indoxyl Sulfate (IS) ELISA Kit
abx257961-96tests 96 tests
EUR 746

Human IS(serum indoxyl sulfate) ELISA Kit
EH4913 96T
EUR 567.6
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75 ng/ml

MHC Class I H-2Kd (H2-Kd) Antibody
abx412710-2ml 2 ml
EUR 606

Centrosomal Protein of 126 KD (Uncharacterized protein KIAA1377) Antibody
20-abx110337
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

KD Plus DNA Polymerase (with 2.5 mM dNTPs) Enzyme
abx071023-100U 100 U
EUR 244

KD Plus DNA Polymerase (with 2.5 mM dNTPs) Enzyme
abx071023-1200U 1200 U
EUR 926

KD Plus DNA Polymerase (with 2.5 mM dNTPs) Enzyme
abx071023-200U 200 U
EUR 314

Rabbit Phosphorylase b kinase regulatory subunit alpha, liver is
ELI-08786Ra 96 Tests
EUR 928

Purified Recombinant Anthrax Protective Antigen (83 kD) (Non toxic), vaccine grade
AV-9140-100 100 ug
EUR 651

Purified Recombinant Anthrax Protective Antigen (83 kD) (Non toxic), vaccine grade
AV-9140-1000 1 mg
EUR 2425

Purified Recombinant Anthrax Protective Antigen (PA83 kD) protein control for WB
PA17-C 100 ul
EUR 286

Purified Recombinant Anthrax Protective Antigen (20 kD/PA20) protein control for WB
PA20-C 100 ul
EUR 286

Purified Recombinant Anthrax Protective Antigen (63 kD/PA63) protein control for WB
PA63-C 100 ul
EUR 286

Keyhole Limpet Hemocyanin (KLH)-Agarose af is finity gel for removing KLH antibodies
KLH11-G-5 5 ml
EUR 529

TruStrip RDT Clenbuterol rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100010-RDT 1 pk Ask for price

TruStrip RDT Quinolone rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100020-RDT 1 pk Ask for price

TruStrip RDT Salbutamal rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100030-RDT 1 pk Ask for price

TruStrip RDT Chloramphenicol rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100040-RDT 1 pk
EUR 651

TruStrip RDT Sulfanethazine rapid test card, results is 2-10 mins, 50 cards/pk
DE-100100-RDT 1 pk Ask for price

TruStrip RDT Ractopamine rapid test strips, results is 2-10 mins, 50 strips/pk
DE-10020-RDT 1 pk Ask for price

TruStrip RDT Gentamicin rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100200-RDT 1 pk Ask for price

TruStrip RDT Streptomycin rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100210-RDT 1 pk Ask for price

TruStrip RDT Melamine rapid test strips, results is 2-10 mins, 50 cards/pk
DE-100270-RDT 1 pk Ask for price

TruStrip RDT Lincomycin rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100630-RDT 1 pk Ask for price

TruStrip RDT Kanamycin rapid test strips, results is 2-10 mins, 50 strips/pk
DE-850101-RDT 1 pk Ask for price

TruStrip RDT Nitrofuran (AOZ) rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100060-RDT 1 pk Ask for price

TruStrip RDT Nitrofuran (AHD rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100070-RDT 1 pk Ask for price

TruStrip RDT Nitrofuran (SEM) rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100075-RDT 1 pk Ask for price

TruStrip RDT Nitrofuran (AOZ) rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100080-RDT 1 pk
EUR 651

TruStrip RDT Malachite green rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100280-RDT 1 pk Ask for price

TruStrip RDT Aflatoxin B1 rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100290-RDT 1 pk Ask for price

TruStrip RDT Total Aflatoxins rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100300-RDT 1 pk Ask for price

TruStrip RDT Aflatoxin M1 rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100330-RDT 1 pk Ask for price

TruStrip RDT Sulfonamides residues (SAs) rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100090-RDT 1 pk
EUR 651

TruStrip RDT Beta-Lactam and Tetracyclines rapid test strips, results is 2-10 mins, 50 strips/pk
DE-100260-RDT 1 pk Ask for price

TruStrip RDT Cow/Bovine Infectious rhinitis (IBR) antibody rapid test card, results is 2-10 mins, 50 cards/pk
RV-500300-RDT 1 pk Ask for price

TruStrip RDT Canine distemper virus (hardpad disease) antigen rapid test card, results is 2-10 mins, 50 cards/pk
RV-501200-RDT 1 pk Ask for price

Placental DNAm was quantified at 43 Cytosine-phosphate-Guanines (CpGs) at LDLR, LRP1, and SCARB1 gene loci using pyrosequencing: 4 CpGs were retained for further analysis. Maternal clinical data were collected at each trimester of pregnancy. Newborns’ data were collected from medical records. Statistical models included minimally newborn sex and gestational and maternal age.

Maternal total cholesterol changes during pregnancy (ΔT3-T1) were correlated with DNAm variations at LDLR (r = -0.32, p = 0.01) and LRP1 (r = 0.34, p = 0.007). DNAm at these loci was also correlated with newborns’ cord blood triglyceride and leptin levels. Mediation analysis supports a causal relationship between maternal cholesterol changes, DNAm levels at LRP1 locus, and cord blood leptin concentration (pmediation = 0.02).

These results suggest that LRP1 DNAm link maternal blood cholesterol changes in pregnancy and offspring adiposity at birth, which provide support for a better follow-up of blood lipids in pregnancy.